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accession-icon GSE67522
Genome-wide analysis of gene expression to identify the probably functionally relevant pathways in cervical cancer progression
  • organism-icon Homo sapiens
  • sample-icon 42 Downloadable Samples
  • Technology Badge IconIllumina HumanHT-12 V4.0 expression beadchip

Description

Identification of genes and pathways relevant to Cervical cancer pathogenesis. The study also aimed at identifying probable mechanistic differences in the low and high HOTAIR expressing cervical cancers patients .

Publication Title

Bridging Links between Long Noncoding RNA HOTAIR and HPV Oncoprotein E7 in Cervical Cancer Pathogenesis.

Sample Metadata Fields

Age, Specimen part

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accession-icon GSE55314
Cerebellar RNA in Grid2 deficient mice.
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430A 2.0 Array (mouse430a2)

Description

Downsream of GRID2 in the mouse cerebellum.

Publication Title

Altered Actions of Memantine and NMDA-Induced Currents in a New Grid2-Deleted Mouse Line.

Sample Metadata Fields

Sex, Age

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accession-icon GSE88743
Expression data from non-infected macrophages treated with conditioned medium from macrophages persistently infected with RSV virus
  • organism-icon Mus musculus
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 2.0 ST Array (mogene20st)

Description

Persistent Respiratory syncytial virus (RSV) infection in humans, animal models and cell lines have proven persistence of viral genomic RNA and mRNA for long periods of time. Cell lines are well-established models that can be used to study alterations in the expression profile of the host genome. We postulate that RSV persistence might also indirectly induce changes in the homeostasis of non-infected cells through soluble factors. Thus, we evaluated the effect of conditioned medium (CM) from MP cultures on the transcriptional profile of non-infected macrophages through gene expression microarrays

Publication Title

No associated publication

Sample Metadata Fields

Specimen part, Cell line

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accession-icon GSE59262
Expression data from U373 cell lines
  • organism-icon Homo sapiens
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Gene 1.0 ST Array (hugene10st)

Description

Intracellular progesterone receptor (PR) presents two main isoforms: PR-A and PR-B with different function and regulation. Both isoforms have been identified in astrocytomas, the most common and aggressive primary brain tumors in humans. To investigate the role of PR activity in the regulation of gene expression pattern of U373 cells, we evaluated by microarray analysis the profile of genes regulated by progesterone (10 nM), by a progesterone receptor antagonist (RU486, 10 M) or by both steroids.

Publication Title

No associated publication

Sample Metadata Fields

Cell line

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accession-icon GSE44029
Expression data from SW480 cells with Gankyrin knockdown
  • organism-icon Homo sapiens
  • sample-icon 5 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

we performed genome-wide screening using SW480 cells with Gankyrin knockdown on an Affymetrix gene expression array to identify the transcriptional targets of Gankyrin

Publication Title

Gankyrin activates IL-8 to promote hepatic metastasis of colorectal cancer.

Sample Metadata Fields

Specimen part, Cell line

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accession-icon SRP090377
Gallus gallus Thrombocyte RNAseq
  • organism-icon Gallus gallus
  • sample-icon 6 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

Characterization of the Gallus gallus thrombocyte transcriptome under control and LPS stimulated conditions

Publication Title

No associated publication

Sample Metadata Fields

Sex, Age, Specimen part, Cell line, Treatment

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accession-icon SRP181468
Comparative gene expression profiles in parathyroid adenoma and normal parathyroid tissue
  • organism-icon Homo sapiens
  • sample-icon 15 Downloadable Samples
  • Technology Badge IconIllumina HiSeq 2500

Description

Transcriptome analysis to compare parathyroid adenomas and normal parathyroid glands with the aim of identifying differentially expressed genes

Publication Title

No associated publication

Sample Metadata Fields

Sex, Age, Specimen part, Disease, Race

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accession-icon GSE11516
Circadian Rhythm of Gene Expression Patterns in Liver of Mouse
  • organism-icon Mus musculus
  • sample-icon 36 Downloadable Samples
  • Technology Badge IconMouseWG-6 V2

Description

Genes encoding the circadian pacemaker in the hypothalamic suprachiasmatic nuclei (SCN) of mammals have recently been identified, but the molecubasis of circadian timing in peripheral tissue is not well understood. We used a bead-based microarray to identify mouse liver transcripts that show circadian cycles of abundance under constant conditions.

Publication Title

Comprehensive analysis of microRNA-mRNA co-expression in circadian rhythm.

Sample Metadata Fields

Sex, Age, Specimen part

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accession-icon DRP001153
Transcriptome analysis in TMPRSS2 KO mice.
  • organism-icon Mus musculus
  • sample-icon 2 Downloadable Samples
  • Technology Badge IconIllumina Genome Analyzer IIx

Description

The type II transmembrane serine protease, TMPRSS2, which is expressed in the epithelia of the respiratory tract and can activate varieties of respiratory viruses. We have generated TMPRSS2 knockout (KO) mice. These mice showed normal development, growth, and fertility phenotypes, compared with wild-type mice.

Publication Title

No associated publication

Sample Metadata Fields

No sample metadata fields

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accession-icon GSE54437
Expression data of K562 cells with KLF3 deficiency and shRNA vector control
  • organism-icon Homo sapiens
  • sample-icon 4 Downloadable Samples
  • Technology Badge IconIllumina HumanHT-12 V4.0 expression beadchip

Description

KLF3, a member of the Krppel-like factor (KLF) family, is expressed in a wide range of cell types. It is involved in hematopoiesis of several blood cell lineages including erythrocyte and B lymphocyte. However, the research of regulatory roles on hematopoiesis of KLF3 in K562 cells has been still largely limited. To comprehensively assess the regulatory roles of KLF3 on hematopoiesis in K562 cells, a microarray analysis was performed in KLF3-deficient K562 cells. The differentially expressed genes were applied to IPA analysis to observe the perturbed hematopoiesis-associated functions, networks, and molecular pathways. This study will extensively assess the regulatory roles of KLF3 on hematopoiesis in K562 cells.

Publication Title

No associated publication

Sample Metadata Fields

Cell line

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...

refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

fund-icon Fund the CCDL

Developed by the Childhood Cancer Data Lab

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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