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accession-icon GSE140945
Mouse transcriptome reveals signatures of protection and pathogenesis in human tuberculosis
  • organism-icon Mus musculus
  • sample-icon 48 Downloadable Samples
  • Technology Badge IconIllumina MouseWG-6 v2.0 expression beadchip

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis.

Sample Metadata Fields

Sex, Specimen part

View Samples
accession-icon GSE140943
Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis [blood array]
  • organism-icon Mus musculus
  • sample-icon 26 Downloadable Samples
  • Technology Badge IconIllumina MouseWG-6 v2.0 expression beadchip

Description

Characterisation of blood and lung global transcriptional responses to Mycobacterium tuberculosis infection in distinct mouse models of Tuberculosis

Publication Title

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE140944
Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis [lung array]
  • organism-icon Mus musculus
  • sample-icon 22 Downloadable Samples
  • Technology Badge IconIllumina MouseWG-6 v2.0 expression beadchip

Description

Characterisation of blood and lung global transcriptional responses to Mycobacterium tuberculosis infection in distinct mouse models of Tuberculosis

Publication Title

Mouse transcriptome reveals potential signatures of protection and pathogenesis in human tuberculosis.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE136883
Gene expression from MS5 stroma cells co-cultured with normal human hematopoietic progenitors/stem cells (HSPCs) and AML
  • organism-icon Mus musculus
  • sample-icon 3 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

Acute myeloid leukemia remodels the bone marrow non-hematopoietic microenvironment which disrupts niche archiecture and normal hematopoiesis The precise interactions underlying this process are not well understood

Publication Title

No associated publication

Sample Metadata Fields

Specimen part, Cell line

View Samples
accession-icon GSE76296
ATMIN function in p53-deficient GBM
  • organism-icon Mus musculus
  • sample-icon 8 Downloadable Samples
  • Technology Badge IconIllumina MouseRef-8 v2.0 expression beadchip

Description

We report the expression anaysis of neural stem cells lacking p53, ATMIN, or both. p53-deficent cells form GBM, which is significanly delayed in the absence of ATMIN.

Publication Title

Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation.

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE89809
Multi-tissue transcriptomics delineates the diversity of airway T cells functions in asthma
  • organism-icon Homo sapiens
  • sample-icon 145 Downloadable Samples
  • Technology Badge Icon Affymetrix HT HG-U133+ PM Array Plate (hthgu133pluspm)

Description

Asthma arises from the complex interplay of inflammatory pathways in diverse cell types and tissues including epithelial and T cells.

Publication Title

Multitissue Transcriptomics Delineates the Diversity of Airway T Cell Functions in Asthma.

Sample Metadata Fields

Sex, Subject

View Samples
accession-icon GSE64913
Altered epithelial gene expression in peripheral airways of severe asthma
  • organism-icon Homo sapiens
  • sample-icon 70 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Management of severe asthma remains a challenge despite treatment with glucocorticosteroid therapy. The majority of studies investigating disease mechanisms in treatment-resistant severe asthma have previously focused on the large central airways, with very few utilizing transcriptomic approaches. The small peripheral airways, which comprise the majority of the airway surface area, remain an unexplored area in severe asthma and were targeted for global epithelial gene expression profiling in this study.

Publication Title

Altered Epithelial Gene Expression in Peripheral Airways of Severe Asthma.

Sample Metadata Fields

Sex, Age, Specimen part, Disease, Subject

View Samples
accession-icon GSE91012
UV-Irradiation Induces a Noncoding RNA that Functionally Opposes the Protein Encoded by the Same Gene
  • organism-icon Homo sapiens
  • sample-icon 13 Downloadable Samples
  • Technology Badge IconIllumina HumanHT-12 V4.0 expression beadchip

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

UV Irradiation Induces a Non-coding RNA that Functionally Opposes the Protein Encoded by the Same Gene.

Sample Metadata Fields

Cell line, Treatment, Time

View Samples
accession-icon GSE37387
Transcript levels in mouse liver
  • organism-icon Mus musculus
  • sample-icon 24 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Description

Total RNA was isolated from liver samples of C57/BL6 mice over a circadian time course, 3 biological replicate samples per time point were collected and processed individually. RNA from each individual biological replicate sample was extracted using RNeasy mini kit (Qiagen Cat# 74106) and hybridized on an Affymetrix mouse Gene ST1.0 microarray.

Publication Title

Histone methyltransferase MLL3 contributes to genome-scale circadian transcription.

Sample Metadata Fields

Specimen part, Time

View Samples
accession-icon GSE114669
OnPLS-based multi-block data integration: a multivariate approach to interrogating biological interactions in asthma
  • organism-icon Homo sapiens
  • sample-icon 22 Downloadable Samples
  • Technology Badge Icon Affymetrix HT HG-U133+ PM Array Plate (hthgu133pluspm)

Description

Integration of multi-omics data remains a key challenge in fulfilling the potential of comprehensive systems biology.

Publication Title

OnPLS-Based Multi-Block Data Integration: A Multivariate Approach to Interrogating Biological Interactions in Asthma.

Sample Metadata Fields

Sex, Age, Specimen part, Disease, Disease stage

View Samples

refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

fund-icon Fund the CCDL

Developed by the Childhood Cancer Data Lab

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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