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accession-icon GSE11987
Expression data from GLI1-transformed RK3E cells
  • organism-icon Rattus norvegicus
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Rat Genome 230 2.0 Array (rat2302)

Description

SHH signaling pathway is activated in many type of cancers. However, the role of its activation in particular type of cancer was poorly understood. The GLI family transcription factor GLI1 is the effector of Shh pathway activation and functions as oncogene. Our goal of research is to identify the GLI1 targets in desmoplastic medulloblastomas.

Publication Title

Defining a role for Sonic hedgehog pathway activation in desmoplastic medulloblastoma by identifying GLI1 target genes.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE10320
Predicting Relapse in Favorable Histology Wilms Tumor Using Gene Expression
  • organism-icon Homo sapiens
  • sample-icon 144 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A Array (hgu133a)

Description

The gene expression patterns of favorable histology Wilms tumors (FHWT) that relapsed were compared with those that did not relapse using oligonucleotide arrays

Publication Title

Predicting relapse in favorable histology Wilms tumor using gene expression analysis: a report from the Renal Tumor Committee of the Children's Oncology Group.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE14767
Subsets of very low risk Wilms Tumors show distinctive gene expression, histologic, and clinical features
  • organism-icon Homo sapiens
  • sample-icon 39 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A Array (hgu133a)

Description

The goal of this study is to define biologically distinct subsets of Very Low Risk Wilms Tumors (VLRWT) using oligonucleotide arrays.

Publication Title

Subsets of very low risk Wilms tumor show distinctive gene expression, histologic, and clinical features.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE61628
Mst1/2-Yap in lung epithelial progenitor cells
  • organism-icon Mus musculus, Homo sapiens
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung.

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE61582
Microarray of Mst1/2 deleted epithelial cells from E18.5 mouse lungs
  • organism-icon Mus musculus
  • sample-icon 2 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Gene 1.0 ST Array (mogene10st)

Description

ShhCre;Mst1/2flx/flx (Mst1/2 D/D) mice were generated to conditionally delete Mst1 and Mst2 from epithelial progenitors during lung morphogenesis. Lungs from E18.5 control and Mst1/2 D/D mice were mechanically and enzymatically dissociated to generate single cell suspension. Epcam(+) cells were isolated using magnetic microbeads.

Publication Title

Hippo/Yap signaling controls epithelial progenitor cell proliferation and differentiation in the embryonic and adult lung.

Sample Metadata Fields

Specimen part

View Samples
accession-icon GSE4817
Sphingosine 1-phosphate effect on glioblastoma cells in vitro
  • organism-icon Homo sapiens
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A Array (hgu133a)

Description

Abstract

Publication Title

Text mining of full-text journal articles combined with gene expression analysis reveals a relationship between sphingosine-1-phosphate and invasiveness of a glioblastoma cell line.

Sample Metadata Fields

No sample metadata fields

View Samples
accession-icon GSE23183
Differential Gene Expression of Soluble CD8+ T-cell mediated suppression of HIV replication in three older children
  • organism-icon Homo sapiens
  • sample-icon 3 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Goal: To compare the gene expression profiles from pediatric patients with each other, with those reported in adults and in those related to exosomes.

Publication Title

Differential gene expression of soluble CD8+ T-cell mediated suppression of HIV replication in three older children.

Sample Metadata Fields

Sex, Specimen part

View Samples
accession-icon GSE69925
Gene expression profiling of esophageal squamous cell carcinomas
  • organism-icon Homo sapiens
  • sample-icon 256 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

To identify the specific genes for subtyping.

Publication Title

Discovery of a Good Responder Subtype of Esophageal Squamous Cell Carcinoma with Cytotoxic T-Lymphocyte Signatures Activated by Chemoradiotherapy.

Sample Metadata Fields

Specimen part, Disease, Disease stage

View Samples
accession-icon GSE22954
Artificially induced epithelial-mesenchymal transition in surgical subjects: its implications in clinical and basic cancer research
  • organism-icon Homo sapiens
  • sample-icon 144 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U95A Array (hgu95a), Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

Artificially induced epithelial-mesenchymal transition in surgical subjects: its implications in clinical and basic cancer research.

Sample Metadata Fields

Specimen part, Disease, Disease stage, Subject

View Samples
accession-icon GSE33103
Overall aiEMT in surgical samples of esophageal cancer patients
  • organism-icon Homo sapiens
  • sample-icon 96 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U95A Array (hgu95a)

Description

Surgical samples have long been used as important subjects for cancer research. In accordance with an increase of neoadjuvant therapy, biopsy samples have recently become imperative for cancer transcriptome. On the other hand, both biopsy and surgical samples are available for expression profiling for predicting clinical outcome by adjuvant therapy; however, it is still unclear whether surgical sample expression profiles are useful for the prediction by the use of biopsy samples because little has been done about comparative gene expression profiling between the two kinds of samples.

Publication Title

Artificially induced epithelial-mesenchymal transition in surgical subjects: its implications in clinical and basic cancer research.

Sample Metadata Fields

Specimen part, Disease, Disease stage

View Samples
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refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

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Developed by the Childhood Cancer Data Lab

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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