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accession-icon GSE20186
Systematic meta-analysis and replication of genome-wide expression studies of Parkinson's disease
  • organism-icon Homo sapiens
  • sample-icon 36 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A Array (hgu133a), Illumina HumanHT-12 V3.0 expression beadchip

Description

This SuperSeries is composed of the SubSeries listed below.

Publication Title

PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.

Sample Metadata Fields

Sex, Age, Specimen part, Disease

View Samples
accession-icon GSE20146
Expression analysis of dissected GPi in Parkinson's disease
  • organism-icon Homo sapiens
  • sample-icon 20 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Genome-wide transcriptome analysis of expression changes in Globus Pallidus interna (GPi) from Parkinson's disease brain tissue versus control brain tissue.

Publication Title

PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.

Sample Metadata Fields

Sex, Specimen part, Disease, Disease stage

View Samples
accession-icon GSE20141
Expression analysis of laser-dissected SNpc neurons in Parkinson's disease
  • organism-icon Homo sapiens
  • sample-icon 16 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Genome-wide transcriptome analysis of expression changes in laser-dissected SNpc neurons from Parkinson's disease brain tissue versus control brain tissue.

Publication Title

PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.

Sample Metadata Fields

Specimen part, Disease, Disease stage

View Samples
accession-icon GSE20163
Systematic meta-analysis and replication of genome-wide expression studies of Parkinson's disease: 2
  • organism-icon Homo sapiens
  • sample-icon 17 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A Array (hgu133a)

Description

Systematic meta-analysis and replication of genome-wide expression studies identifies molecular pathways of Parkinson's disease.

Publication Title

PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.

Sample Metadata Fields

Age, Specimen part, Disease

View Samples
accession-icon GSE20153
Expression analysis of lymphoblast cells lines in Parkinson's disease
  • organism-icon Homo sapiens
  • sample-icon 12 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Description

Genome-wide transcriptome analysis of expression changes in EBV transformed cell lines from the Coriell Cell Repository in Parkinson and Control subjects.

Publication Title

PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.

Sample Metadata Fields

Sex, Disease, Disease stage

View Samples
accession-icon GSE20164
Systematic meta-analysis and replication of genome-wide expression studies of Parkinson's disease: 3
  • organism-icon Homo sapiens
  • sample-icon 11 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A Array (hgu133a)

Description

Systematic meta-analysis and replication of genome-wide expression studies identifies molecular pathways of Parkinson's disease.

Publication Title

PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.

Sample Metadata Fields

Sex, Age, Specimen part, Disease

View Samples
accession-icon GSE20314
Systematic meta-analysis and replication of genome-wide expression studies of Parkinsons disease: 4
  • organism-icon Homo sapiens
  • sample-icon 8 Downloadable Samples
  • Technology Badge Icon Affymetrix Human Genome U133A Array (hgu133a)

Description

Analysis of substantia nigra from postmortem brains of 4 patients with Parkinsons disease (PD). Results provide insight into the molecular processes perturbed in the PD substantia nigra.

Publication Title

PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease.

Sample Metadata Fields

Sex, Age, Specimen part, Disease

View Samples
accession-icon GSE46970
Gene expression of 4, 5, and 6 days differentiated Flk1+ WT ES cells, and of 6 days differentiated Flk1+ Runx1-/- and Tal-1-/- ES cells
  • organism-icon Mus musculus
  • sample-icon 15 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

In order to identify genes that are activated in differentiating WT ESCs, but are missing in Tal-1-/- and Runx1-/- ESCs, and which might be involved in the generation of definitive hematopoietic progenitors and their specification thereafter, we performed microarray analyses on purified Flk-1+ cells, differentiated from these ESCs for 4, 5, and 6 days in vitro.

Publication Title

Ectopic Runx1 expression rescues Tal-1-deficiency in the generation of primitive and definitive hematopoiesis.

Sample Metadata Fields

Specimen part, Cell line, Time

View Samples
accession-icon GSE47210
Gene expression of murine iDCs isolated from tolerized MOG35-55-infused/MOG35-55-immunized or MOG35-55-immunized mice
  • organism-icon Mus musculus
  • sample-icon 6 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

Recent data from our group, demonstrate that infusion of myelin oligodendrocyte glycoprotein (MOG35-55) peptide, leads to induction of MOG35-55-specific Tregs and subsequent suppression of Experimental Autoimmune Encephalomyelitis (EAE), the mouse model of multiple sclerosis. Amelioration of EAE was accompanied by reduced MOG-specific Th1 and Th17 responses in the draining lymph nodes (dLNs). Phenotypic analysis of the dLNs of MOG-infused mice revealed a significant Treg-mediated reduction in the recruitment of 7AAD-CD3-CD19-CD11c+CD11bhighGr-1+ iDCs compared to non-infused control immunized mice. Focusing on the delineation of novel molecules/genes that are involved in the MOG-specific Treg-mediated suppression of autoimmune responses, we have isolated highly purified iDCs from MOG infused and non-infused control immunized mice.

Publication Title

De novo-induced self-antigen-specific Foxp3+ regulatory T cells impair the accumulation of inflammatory dendritic cells in draining lymph nodes.

Sample Metadata Fields

Sex, Specimen part

View Samples
accession-icon GSE47643
Gene expression of in vitro cultivated preB cells before and after 8, 16 and 24 hours induction of miR-221
  • organism-icon Mus musculus
  • sample-icon 12 Downloadable Samples
  • Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Description

PreB cells were analyzed for differences in gene expression before and after the overexpression of miR-221. In order to dissect possible targets for the miR-221, gene expression profiles of preB cells un-induced or induced for the miR-221 expression after 8, 16 and 24 hours were compared. All induction time-points, e.g. after 8, 16 and 24 hours were compared to un-induced preB cells and to each other group.

Publication Title

SiPaGene: A new repository for instant online retrieval, sharing and meta-analyses of GeneChip expression data.

Sample Metadata Fields

Specimen part

View Samples
...

refine.bio is a repository of uniformly processed and normalized, ready-to-use transcriptome data from publicly available sources. refine.bio is a project of the Childhood Cancer Data Lab (CCDL)

fund-icon Fund the CCDL

Developed by the Childhood Cancer Data Lab

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Cite refine.bio

Casey S. Greene, Dongbo Hu, Richard W. W. Jones, Stephanie Liu, David S. Mejia, Rob Patro, Stephen R. Piccolo, Ariel Rodriguez Romero, Hirak Sarkar, Candace L. Savonen, Jaclyn N. Taroni, William E. Vauclain, Deepashree Venkatesh Prasad, Kurt G. Wheeler. refine.bio: a resource of uniformly processed publicly available gene expression datasets.
URL: https://www.refine.bio

Note that the contributor list is in alphabetical order as we prepare a manuscript for submission.

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