MiR-26 dampens IL-6 production by down-regulating TNF-a/NF-kB signaling through silencing HMGA1 and MALT1 and not by directly targeting IL-6 mRNA

Build and Download Custom Datasets

refine.bio helps you build ready-to-use datasets with normalized transcriptome data from all of the world’s genetic databases.

SRP060719

Homo sapiens

8 Downloadable Samples

Illumina HiSeq 2000

Submitter Supplied Information

Description

We found NF-kB signaling as a major target of miR-26 based on an analysis of the changes in gene activation by TNF-a in response to alteration of miR-26 levels. Overall design: Transcriptional profiling of genes in response to either a miR-26 mimic or miR-26 antagomir.

PubMed ID

27025651

Publication Title

MiR-26 down-regulates TNF-α/NF-κB signalling and IL-6 expression by silencing HMGA1 and MALT1.

Total Samples

Submitter’s Institution

No associated institution

Authors

Chen CY, Chang JT, Ho YF, Shyu AB

Source Repository

Sequence Read Archive (SRA)

No rows found