Whole genome expression data from female adult Drosophila melanogaster midguts

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GSE99071

Drosophila melanogaster

6 Downloadable Samples

Affymetrix Drosophila Genome 2.0 Array (drosophila2)

Submitter Supplied Information

Description

The highly conserved Wnt signaling pathway drives intestinal homeostasis across species. Apc is a negative regulator of Wnt signaling. Loss of function mutations in Apc are found in 80-90% of human colorectal cancers. Importantly, Apc loss is widely known as the key driving event in the disease.

PubMed ID

28708826

Publication Title

Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing.

Total Samples

Submitter’s Institution

University of Glasgow

Authors

Tian A, Benchabane H, Wang Z, Zimmerman C, Xin N, Perochon J, Kalna G, Sansom OJ, Cheng C, Cordero JB, Ahmed Y

Source Repository

Gene Expression Omnibus (GEO)

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