Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition

GSE80657

Homo sapiens

36 Downloadable Samples

Illumina HumanHT-12 V4.0 expression beadchip

Submitter Supplied Information

Description

We aimed to investigate gene expression associated with radiosensitisation of normoxic and hypoxic prostate cancer cells by the class I/II histone deacetylase inhibitor (HDACi) vorinostat.

PubMed ID

27599042

Publication Title

Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition.

Total Samples

Submitter’s Institution

Oslo University Hospital

Authors

Jonsson M, Ragnum HB, Julin CH, Yeramian A, Clancy T, Frikstad KM, Seierstad T, Stokke T, Matias-Guiu X, Ree AH, Flatmark K, Lyng H

Source Repository

Gene Expression Omnibus (GEO)

GSM2132490

DU145-norm_solvent_3

du 145

untreated

GSM2132487

DU145-hypo_solvent_2

du 145

hypoxia exposed (0.2% o2, 24h)

GSM2132516

22Rv1-norm_vorinostat_3

22rv1

vorinostat exposed (1 um, 24h)

GSM2132513

22Rv1-hyp_vorinostat_2

22rv1

vorinostat (1 um, 24h) and hypoxia (0.2% o2, 24h) exposed

GSM2132496

PC-3-norm_vorinostat_1

pc-3

vorinostat exposed (1 um, 24h)

GSM2132489

DU145-hypo_vorinostat_2

du 145

vorinostat (1 um, 24h) and hypoxia (0.2% o2, 24h) exposed

GSM2132495

PC-3-hypo_solvent_1

pc-3

hypoxia exposed (0.2% o2, 24h)

GSM2132511

22Rv1-hyp_solvent_2

22rv1

hypoxia exposed (0.2% o2, 24h)

GSM2132486

DU145-norm_solvent_2

du 145

untreated

GSM2132488

DU145-norm_vorinostat_2

du 145

vorinostat exposed (1 um, 24h)