IFN influences epithelial anti-viral responses via histone methylation of the RIG-I promoter

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GSE77154

Homo sapiens

8 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

This in-vitro study suggests the inflammatory environment of naive epithelial cells can induce epigenetic modulation of innate immune responses at the level of histone methylation and potentially lead to long-term impacts on anti-viral immunity.

PubMed ID

28481620

Publication Title

IFN-γ Influences Epithelial Antiviral Responses via Histone Methylation of the RIG-I Promoter.

Total Samples

Submitter’s Institution

The Francis Crick Institute

Authors

Spalluto CM, Singhania A, Cellura D, Woelk CH, Sanchez-Elsner T, Staples KJ, Wilkinson TMA

Source Repository

Gene Expression Omnibus (GEO)

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