Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium

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GSE65005

Mus musculus

6 Downloadable Samples

Illumina MouseWG-6 v2.0 expression beadchip

Submitter Supplied Information

Description

Conditional knockout of Snai1 in the mouse intestinal epithlium results in apoptotic loss of crypt base columnar cells and bias towards differentiation of secretory lineages. In vitro organoid cultures derived from Snail conditional knockout mice also undergo apoptosis when Snai1 is deleted.

PubMed ID

25759216

Publication Title

Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium.

Total Samples

Submitter’s Institution

University of Melbourne

Authors

Horvay K, Jardé T, Casagranda F, Perreau VM, Haigh K, Nefzger CM, Akhtar R, Gridley T, Berx G, Haigh JJ, Barker N, Polo JM, Hime GR, Abud HE

Source Repository

Gene Expression Omnibus (GEO)

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