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Accession IconGSE33156

Hedgehog signaling in T cell differentiation

Organism Icon Mus musculus
Sample Icon 18 Downloadable Samples
Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description
Despite Hedgehogs influence on T-cell activation and proliferation, the transcriptional targets of Gli2 in lymphocytes are not known. We therefore examined the Hedgehog-dependent transcriptional response of resting and early-stage activated T-cells in order to define their transcriptional response to Hedgehog pathway activation.
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Total Samples
18
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Samples

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Unstimulated Gli2A Tg CD4 T cells, rep3
cd4 t cells
unstimulated
Unstimulated Gli2A Tg CD4 T cells, rep2
cd4 t cells
unstimulated
Unstimulated Gli2R Tg CD4 T cells, rep2
cd4 t cells
unstimulated
Stimulated Gli2R Tg CD4 T cells, rep3
cd4 t cells
stimulated with anti-cd3/cd28
Stimulated Gli2A Tg CD4 T cells, rep3
cd4 t cells
stimulated with anti-cd3/cd28
Unstimulated WT CD4 T cells, rep1
cd4 t cells
unstimulated
Unstimulated WT CD4 T cells, rep3
cd4 t cells
unstimulated
Unstimulated Gli2R Tg CD4 T cells, rep3
cd4 t cells
unstimulated
Stimulated WT CD4 T cells, rep3
cd4 t cells
stimulated with anti-cd3/cd28
Stimulated Gli2A Tg CD4 T cells, rep2
cd4 t cells
stimulated with anti-cd3/cd28
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