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Accession IconGSE30979

Gene expression in hypoxic non-small cell lung cancer

Organism Icon Homo sapiens
Sample Icon 20 Downloadable Samples
Technology Badge Icon Affymetrix Human Gene 1.0 ST Array (hugene10st)

Submitter Supplied Information

Description
Hypoxia triggers aggressive cancer growth and contributes to chemotherapy resistance. Novel therapeutic strategies aim at targeting hypoxia activated signaling pathways. Tumor hypoxia not only affects neoplastic tumor cells but also the surrounding stroma cells. Therefore, a novel ex vivo model was established, which allows the study of hypoxia effects in fragments of non-small cell lung cancer (NSCLC) with preserved tumor microenvironment and 3D-structure. Microarray analysis identified 107 significantly regulated genes with at least two-fold expression change in hypoxic compared to normoxic fragments. However, only four genes were significantly regulated in both subtypes, adenocarcinoma and squamous cell carcinoma. The hypoxic regulation of these four genes was verified in an independent set using quantitative PCR.
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20
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Samples

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Hypoxic NSCLC fragments patient #1410
non-small cell lung cancer (nsclc)
hypoxia
Hypoxic NSCLC fragments patient #1210
non-small cell lung cancer (nsclc)
hypoxia
Normoxic NSCLC fragments patient #1310
non-small cell lung cancer (nsclc)
normoxia
Hypoxic NSCLC fragments patient #1409
non-small cell lung cancer (nsclc)
hypoxia
Hypoxic NSCLC fragments patient #1209
non-small cell lung cancer (nsclc)
hypoxia
Hypoxic NSCLC fragments patient #1309
non-small cell lung cancer (nsclc)
hypoxia
Normoxic NSCLC fragments patient #3609
non-small cell lung cancer (nsclc)
normoxia
Normoxic NSCLC fragments patient #1309
non-small cell lung cancer (nsclc)
normoxia
Hypoxic NSCLC fragments patient #3609
non-small cell lung cancer (nsclc)
hypoxia
Normoxic NSCLC fragments patient #1210
non-small cell lung cancer (nsclc)
normoxia
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