Gene expression changes associated with resistance to intravenous corticosteroid therapy in children with severe ulcerative colitis

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GSE21231

Homo sapiens

40 Downloadable Samples

Affymetrix Human Gene 1.0 ST Array (hugene10st)

Submitter Supplied Information

Description

Although corticosteroids remain a mainstay of therapy for UC, a meta-regression of cohort studies in acute severe ulcerative colitis (UC) showed that 29% of patients fail corticosteroid therapy and require escalation of medical management or colectomy.

PubMed ID

20941359

Publication Title

Gene expression changes associated with resistance to intravenous corticosteroid therapy in children with severe ulcerative colitis.

Total Samples

Submitter’s Institution

Mount Sinai Hospital

Authors

Kabakchiev B, Turner D, Hyams J, Mack D, Leleiko N, Crandall W, Markowitz J, Otley AR, Xu W, Hu P, Griffiths AM, Silverberg MS

Source Repository

Gene Expression Omnibus (GEO)

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