Exposure of Barrett's associated adenocarcinoma cell lines SKGT4 to deoxycholic acid (DCA)

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GSE13376

Homo sapiens

15 Downloadable Samples

Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

Submitter Supplied Information

Description

The involvment of bile acids such as deoxycholic acid (DCA) in gastro-esophageal reflux disease and subsequent Barretts metaplsia has been postulated. This study examines gene expression induced by exposure to DCA in esophageal cells and may be utilised in cross-comparisons with data derived from gene expression studies of Barretts esophagus and associated adenocarcinoma.

PubMed ID

20139130

Publication Title

An integrative genomic approach in oesophageal cells identifies TRB3 as a bile acid responsive gene, downregulated in Barrett's oesophagus, which regulates NF-kappaB activation and cytokine levels.

Total Samples

Submitter’s Institution

Institute of Molecular Medicine

Authors

Duggan SP, Behan FM, Kirca M, Smith S, Reynolds JV, Long A, Kelleher D

Source Repository

Gene Expression Omnibus (GEO)

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