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Accession IconGSE103007

Variants of DNMT3A cause transcript-specific gene expression changes

Organism Icon Homo sapiens
Sample Icon 24 Downloadable Samples
Technology Badge Icon Affymetrix Human Gene 1.0 ST Array (hugene10st)

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Description
The de novo DNA methyltransferase 3A (DNMT3A) plays a pivotal role in hematopoietic differentiation. In this study, we followed the hypothesis that alternative splicing of DNMT3A has characteristic epigenetic and functional sequels. Various transcripts of DNMT3A were either knocked down or overexpressed in human hematopoietic stem and progenitor cells resulting in complementary and transcript-specific DNA methylation (DNAm) and gene expression changes. Our results demonstrate that different splice variants of DNMT3A have distinct epigenetic and functional sequels.
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24
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HSC_2 KD Tr.4
cd34+ hscs
HSC_4 OE Tr.1+3
cd34+ hscs
HSC_1 KD Tr.1+3
cd34+ hscs
HSC_1 Scramble
cd34+ hscs
HSC_4 Empty
cd34+ hscs
HSC_6 OE Tr.4
cd34+ hscs
HSC_1 KD Tr.4
cd34+ hscs
HSC_2 Scramble
cd34+ hscs
HSC_2 KD Tr.1+3
cd34+ hscs
HSC_4 OE Tr.4
cd34+ hscs
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